[Immune reactions that mediate tubulointerstitial nephritis].

  • Shinnosuke Ueda
  • Published 1995 in
    Nihon rinsho. Japanese journal of clinical…

Abstract

Experimental autoimmune tubulointerstitial nephritis (TIN) is induced by immunization with TBM antigen and adjuvant in guinea pigs, rats, and mice. In animal models, both anti-TBM autoantibody and TBM-sensitized T cells have important roles in development of TIN. Antibodies deposited on TBM bind with complements, and these complexes induce infiltration of… (More)

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