Experimental autoimmune tubulointerstitial nephritis (TIN) is induced by immunization with TBM antigen and adjuvant in guinea pigs, rats, and mice. In animal models, both anti-TBM autoantibody and TBM-sensitized T cells have important roles in development of TIN. Antibodies deposited on TBM bind with complements, and these complexes induce infiltration of… (More)
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