[Hysteresis behavior of complex I from bovine heart mitochondria: kinetic and thermodynamic parameters of retarded reverse transition from the inactive to active state].

Abstract

Isolated Complex I exists in two forms. The active form catalyzes the rapid rotenone-sensitive, N-ethylmaleimide-insensitive NADH : Q1 reductase reaction. The inactive form is inhibited by N-ethylmaleimide and catalyzes the rotenone-sensitive ubiquinone reduction with a prominent lag phase. The inactive enzyme is transformed into its active form after rapid… (More)

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