Corpus ID: 26651990

[Hypolactatemic effect of sodium difluoroacetate].

  title={[Hypolactatemic effect of sodium difluoroacetate].},
  author={J M Dalstein and G{\'e}rard Ribes and P Campo and Marie-Madeleine Loubati{\`e}res-Mariani},
  journal={Comptes rendus des seances de la Societe de biologie et de ses filiales},
  volume={174 5},
In the anesthetized rat, the intraperitoneal injection of 40 mg/kg sodium difluoroacetate (DFA), an activator of the pyruvate dehydrogenase, counteracted the hyperlactatemia induced by a high dose of phenformin (40 mg/kg) injected concomitantly. In the normal conscious dog, the administration of 150 mg/kg by gastric intubation decreased the blood lactate and pyruvate levels; however, this effect was less marked than that produced by the same dose of sodium dichloroacetate (DCA).