[Hyperuricemia and cardiovascular diseases: from phylogenesys to patogenetic mechanisms].

Abstract

During human evolution, the accumulation of loss of function mutations of the uricase gene led progressively to the lack of the ability to metabolize uric acid into further end-products. Consequently, serum uric acid levels progressively increased over time along with the dietary availability of purine-rich foods. At first, the increase in uricemia… (More)

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Cite this paper

@article{Trepiccione2015HyperuricemiaAC, title={[Hyperuricemia and cardiovascular diseases: from phylogenesys to patogenetic mechanisms].}, author={Francesco Trepiccione and Alessandra Fortunata Perna}, journal={Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia}, year={2015}, volume={32 Suppl 62} }