Hormonal factors moderate the associations between vascular risk factors and white matter hyperintensities.
- MedicineBrain imaging and behavior
In men with testosterone levels one standard deviation higher than the mean value, smoking was associated with 27.8% higher white matter hyperintensities volumes in the whole brain, and in women with a shorter post-menopause duration, diabetes and higher pulse wave velocity were associated with 28.8%.
The imbalance in the aortic ceramide/sphingosine-1-phosphate rheostat in ovariectomized rats and the preventive effect of estrogen
- BiologyLipids in Health and Disease
Ovariectomy resulted in the imbalance of the aortic ceramide/S1P rheostat in rats, which may be a potential mechanism underlying the increase in SBP and PP among perimenopausal women.