[HPLC determination of tetramethylpyrazine in human serum and its pharmacokinetic parameters].

@article{Cai1989HPLCDO,
  title={[HPLC determination of tetramethylpyrazine in human serum and its pharmacokinetic parameters].},
  author={Wei Cai and Sangsoo Dong and Yuze Lou},
  journal={Yao xue xue bao = Acta pharmaceutica Sinica},
  year={1989},
  volume={24 12},
  pages={
          881-6
        }
}
An HPLC method for the determination of tetramethylpyrazine in serum and application of this method to tetramethylpyrazine deposition studies in human body were described. Tetramethylpyrazine was extracted from alkalinized serum with dichloromethane using methaqualone as internal standard. A RP mu-Bondapak-C18 (10 microns) column fitted with a variable-wavelength UV spectrophotometer operated at 280 nm was used. The mobile phase was methanol-water (58:42). The detection limit of the method was… CONTINUE READING

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