[HMG-CoA-reductase inhibitors: a new principle in the treatment of hypercholesterolemia].

Abstract

HMG-CoA reductase inhibitors are a new class of drugs, which inhibit de novo cholesterol biosynthesis and significantly reduces the blood cholesterol concentrations. Three separate inhibitors, lovastatin, simvastatin and pravastatin can lower plasma total cholesterol and low-density lipoprotein (LDL) levels in hypercholesterolemic humans by 20 to 30% and 30… (More)

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