[HER2 gene amplification assay: is CISH an alternative to FISH?].

  title={[HER2 gene amplification assay: is CISH an alternative to FISH?].},
  author={Yves Denoux and Laurent Arnould and Maryse Fiche and B{\'e}atrice Lannes and J{\'e}r{\^o}me Couturier and Anne Vincent-Salomon and Fr{\'e}d{\'e}rique Penault-Llorca and Martine Antoine and Andr{\'e} Balaton and Marie Christine Baranzelli and Val{\'e}rie Becette and J. P. Bellocq and Fr{\'e}d{\'e}ric Bibeau and Francette Ettore and Viviana Fridman and J P Gnassia and Jocelyne D. Jacquemier and Ga{\"e}tan Macgrogan and Marie Christine Mathieu and Claude Migeon and Christophe Rigaud and Pascal Roger and Brigitte Sigal-Zafrani and Jo{\^e}lle Simony-Lafontaine and Martine Trassard and Isabelle 6 Treilleux and V{\'e}ronique Verri{\`e}le and J. J. Voigt},
  journal={Annales de pathologie},
  volume={23 6},
The HER2 proto-oncogene encodes a transmembrane protein, which is considered to function as a growth factor receptor. Overexpression of this protein found by immunohistochemistry in about 20% of infiltrating breast carcinomas, has a predictive value of response to treatment by trastuzumab, an anti-HER2 humanized monoclonal antibody. Search for HER2 gene amplification is necessary to adapt the immunohistochemical technique quality and also in the cases of delicate analysis or weak overexpression… CONTINUE READING