[Good laboratory practice of equilibrium solubility measurement].

  title={[Good laboratory practice of equilibrium solubility measurement].},
  author={Edit Baka},
  journal={Acta pharmaceutica Hungarica},
  volume={81 1},
  • Edit Baka
  • Published 2011 in Acta pharmaceutica Hungarica
The biggest part of my PhD work was the standardization of the classical saturation shake-flask solubility method. During the experiments we examined systematically which parameters have significant influence on the solubility value and how large experimental error (standard deviation) is caused by them in the solubility method. Hydrochlorothiazide was used as model compound. Modification in temperature, sedimentation time, composition of aqueous buffer and the technique of separation of solid… CONTINUE READING