[Glucosamine and chondroitin sulfate do not enhance anticoagulation activity of warfarin in mice in vivo].

@article{Yokotani2014GlucosamineAC,
  title={[Glucosamine and chondroitin sulfate do not enhance anticoagulation activity of warfarin in mice in vivo].},
  author={Kaori Yokotani and Tomoko Nakanishi and Tsuyoshi Chiba and Yoko Sato and Keizo Umegaki},
  journal={Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan},
  year={2014},
  volume={55 4},
  pages={
          183-7
        }
}
As an adverse event, it has been reported that anticoagulation activity of warfarin was enhanced by simultaneous intakes of glucosamine and chondroitin sulfate. However, it is unclear whether these is a causative relation. Therefore, in the present study, we evaluated whether glucosamine and chondroitin sulfate enhanced the anticoagulant action of warfarin in mice in vivo, focusing on hepatic cytochrome P450 (CYPs)-mediated mechanisms. Mice were fed a diet containing various doses of… Expand
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