[Glucocorticoids and their receptor: mechanisms of action and clinical implications].

Abstract

BACKGROUND Glucocorticoids are used as anti-inflammatory, immuno-modulatory, anti-proliferative and cytotoxic drugs, but they also trigger important side-effects. These hormones bind to glucocorticoid receptor alpha (GRalpha), an intracellular protein, which acts essentially in the nucleus. MAIN POINTS GRalpha is a ligand-activated transcription factor… (More)

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