[Germline E-cadherin gene mutation screening in familial gastric cancer kindreds].

Abstract

OBJECTIVE To evaluate the frequency and nature of E-cadherin gene (CDH1) germline mutations in familial gastric cancer kindreds of china. METHODS Five familial gastric cancer kindreds of Chinese origin were screened for germline CDH1 mutations, all of them meeting the clinical criteria for hereditary diffuse gastric cancer (HDGC), by PCR-DHPLC and direct… (More)

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