[Genetic variation-- important for the clinical effect of opioids?].

  title={[Genetic variation-- important for the clinical effect of opioids?].},
  author={P{\aa}l Klepstad and O. B. Dale and Petter Christian Borchgrevink and Stein Kaasa and Frank Skorpen},
  journal={Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke},
  volume={125 19},
The individual variability of opioid pharmacology suggests that the patients' genetic disposition influences the response to opioids. Given the complexity of morphine pharmacology, variability may be caused by several genes. Data suggest that variability in genes encoding the enzyme metabolising morphine (UGT2B7 gene), mu-opioid receptors (OPRM1 gene) and… CONTINUE READING