• Medicine
  • Published in
    Annales de dermatologie et de…
    1995

[Genetic diagnosis of mycobacterium infections by polymerase chain reaction (PCR)].

@article{Perronne1995GeneticDO,
  title={[Genetic diagnosis of mycobacterium infections by polymerase chain reaction (PCR)].},
  author={Christian Perronne and Vuaroqueaux Vincent},
  journal={Annales de dermatologie et de venereologie},
  year={1995},
  volume={122 4},
  pages={
          213-5
        }
}
Diagnosis is often difficult for mycobacteria because of the limitations of both direct microscopy and cell culture. Polymerase chain reaction (PCR), widely developed in microbiology, could provide major progress in the diagnosis of tuberculosis and atypical mycrobacterial diseases. Sensitivity rarely exceeds 80% and can be lower than 60% compared with traditional culture techniques. The specificity of tuberculosis PCR is rarely better than 97% so that the positive predictive value varies from… CONTINUE READING