[Genetic characteristics of scirrhous gastric carcinomas].

  title={[Genetic characteristics of scirrhous gastric carcinomas].},
  author={Hiroshi Yokozaki and Hiroki Kuniyasu and Wataru Yasui and Eiichi Tahara},
  journal={Gan to kagaku ryoho. Cancer & chemotherapy},
  volume={21 14},
Genetic characteristics of scirrhous gastric carcinomas are overviewed. Scirrhous carcinomas of the stomach frequently show amplification of c-met and K-sam oncogenes as well as overexpression of 6.0 kb c-met abnormal transcript. For the formation of productive fibrosis and the diffuse infiltrative growth pattern of this malignancy, the essential factors would be not only the loss of cell adhesion molecule function through depressed expression or loss of cadherin or catenin, but also the… CONTINUE READING

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