[Generalized autoimmune diseases in BALB/c mice with a genetically dependent interleukin-2 deficiency].

Abstract

Il-2 has been described as a key cytokine regulating the growth, differentiation and function of lymphocytes. To better understand its in vivo function Il-2 deficient mouse mutants were generated on a mixed (129/Ola x C57BL6) genetic background which predominantly develop an ulcerative colitis-like disease (10). To further elucidate the complex disease… (More)

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