[Generalization of the Monod-Wyman-Changeux model for the case of multisubstrate reactions].

@article{Popova1976GeneralizationOT,
  title={[Generalization of the Monod-Wyman-Changeux model for the case of multisubstrate reactions].},
  author={Stoylmina Popova and E E Sel'kov},
  journal={Molekuliarnaia biologiia},
  year={1976},
  volume={10 5},
  pages={1116-26}
}
A general equation is derived for the rate of multisubstrate reaction catalyzed by oligomeric enzyme E(R, T) liable to concerted transitions Ro in equilibrium To or Ro in equilibrium 2To. It is shown that with some assumptions about the enzymes the rate equations can be constructed from the rates of corresponding reactions catalyzed by a single active site. These single active site rate equations are known for the majority of catalysis mechanisms, otherwise they can be easily deduced. As an… CONTINUE READING

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