[General pharmacological effects of a psychotropic agent, doxepin hydrochloride].

  title={[General pharmacological effects of a psychotropic agent, doxepin hydrochloride].},
  author={I Otsuki and Jun Ishikawa and M Sakai and K Shimabara and T Momiyama},
  journal={Nihon yakurigaku zasshi. Folia pharmacologica Japonica},
  volume={68 6},
  • I Otsuki, Jun Ishikawa, +2 authors T Momiyama
  • Published 1972
  • Medicine
  • Nihon yakurigaku zasshi. Folia pharmacologica Japonica
  • Doxepin caused a fall in blood pressure accompanied by an increase of peripheral blood flow in dogs. Doxepin potentiated the effect of norepinephrine (NE) on blood pressure and nictitating membrane of cats but reduced the effect of epinephrine (E). The pharmacological properties of doxepin resemble those of amitriptyline but differ from imipramine which exhibits a dual effect on blood pressure and a potentiating effect to both NE and E. Doxepin, however, showed less pronounced anticholinergic… CONTINUE READING

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