[Gene therapy for lung cancer treatment].

  title={[Gene therapy for lung cancer treatment].},
  author={Koichi Takayama and Yoichi Nakanishi and Nobuyuki Hara},
  journal={Nihon rinsho. Japanese journal of clinical medicine},
  volume={58 5},
Gene therapy is a promising strategy for cancer treatment. The strategy is categorized to some fields based on the anti-cancer mechanism. p53 gene therapy and antisense therapy exert the cytotoxic effect on cancer cells by apoptosis induction. In suicide gene therapy, expressed suicide gene product kills the cancer cells in combination with prodrug which metabolite is cytotoxic agent. Oncolytic virus replicates in the tumor selectively and destroys the cancer cells. Immunogene therapy… CONTINUE READING