[Gene methylation in stool for the screening of colorectal cancer and pre-malignant lesions].

@article{Kang2011GeneMI,
  title={[Gene methylation in stool for the screening of colorectal cancer and pre-malignant lesions].},
  author={Yan-Ping Kang and Fu-ao Cao and Wen-Jun Chang and Zheng Lou and Hao Wang and Ling-ling Wu and ChuanGang Fu and Guangwen Cao},
  journal={Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery},
  year={2011},
  volume={14 1},
  pages={52-6}
}
OBJECTIVE To evaluate association between DNA methylation of MAL, CDKN2A, and MGMT in stool and development of colorectal cancer, and to evaluate the screening value of these biomarkers in colorectal cancer and pre-malignant lesions. METHODS Morning stool specimens were collected from 69 patients with colorectal cancer, 24 with colon adenoma, 19 with hyperplastic polyps, and 26 healthy controls. DNA was extracted and treated with bisulfite. Methylation-specific PCR(MSP) was performed for… CONTINUE READING