• Corpus ID: 36501245

[Gas chromatographic method for the quantitative determination of ftoratsizin and its N-dealkylated metabolites in animal and human biological material].

@article{Zherdev1980GasCM,
  title={[Gas chromatographic method for the quantitative determination of ftoratsizin and its N-dealkylated metabolites in animal and human biological material].},
  author={V. P. Zherdev and A. L. {\'E}konomov and Iu I Vikhliaev},
  journal={Farmakologiia i toksikologiia},
  year={1980},
  volume={43 2},
  pages={
          215-8
        }
}

• V. Zherdev, A. L. Ékonomov, Iu I Vikhliaev
• Published 1980
• Chemistry
• Farmakologiia i toksikologiia

Conditions have been selected, providing the most complete transformation of ftoracizin 10-(beta-diethylaminopropionyl)-2-trifluoromethylphenothiazine and its two dealkylated metabolites--deethylftoracizin 10-(beta-ethylaminopropionyl)-2-trifluoromethylphenothiazine and dediethylftoracizin 10-(beta-aminoprpiony 17-2-trifluoromethylphenothiazine to 10-akryloyl-2-trifluoromethylphenothiazine in the injector of a chromatograph. The detector for electrons 63Ni uptake was extremely sensitive to the above substance. A method has been developed for quantitative determination of ftoracizin, diethylftoracizin and dediethylftoracizin in animal and human bioloigcal material.