[GRADE guidelines: 9. Rating up the quality of evidence].

@article{Kien2013GRADEG9,
  title={[GRADE guidelines: 9. Rating up the quality of evidence].},
  author={Christina Kien and Gerald Gartlehner and Angela Kaminski-Hartenthaler and Joerg J Meerpohl and Maria Flamm and Gero Langer and Matthias Perleth and Holger J. Sch{\"u}nemann},
  journal={Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen},
  year={2013},
  volume={107 3},
  pages={249-55}
}
The most common reason for rating up the quality of evidence is a large effect. GRADE suggests considering rating up quality of evidence one level when methodologically rigorous observational studies show at least a two-fold reduction or increase in risk, and rating up two levels for at least a five-fold reduction or increase in risk. Systematic review authors and guideline developers may also consider rating up quality of evidence when a dose-response gradient is present, and when all… CONTINUE READING
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