[Functional concept of the initiation of blood coagulation by cell membranes].


According to the conception proposed, blood coagulation is initiated by Ca(2+)-induced rearrangement of the bilayer structure of native cell membranes into heterophasic. The thrombogenic action is realized through Ca2+ entering the cell cytoplasm. This leads to phosphatidyl serine translocation into the surface monolayer of the membrane, its clustering and… (More)


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