[From heparin to heparins: toward new therapeutic perspectives?].

  title={[From heparin to heparins: toward new therapeutic perspectives?].},
  author={P Molho and G{\'e}rard Tobelem},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  volume={41 4},
Heparin is mainly known for its anticoagulant action, but today other biological effects are investigated. With the low molecular weight heparin fractions (LMWH), more homogenous, a more detailed study of the mechanism of action of heparins can be made. The anticoagulant action of heparin is mainly antithrombin III (AT III) dependent and the binding site of AT III on the heparin molecule has been recently identified. LMWH have a lower anticoagulant (anti-IIa) activity, and a relatively higher… CONTINUE READING


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