[Friend or Foe?--Psoriasin and Koebnerisin: multifunctional defence molecules in skin differentiation, tumorigenesis and inflammation].

Abstract

Psoriasin (S100A7) and koebnerisin (S100A15) were first identified in inflamed psoriatic skin. They have lately evolved by gene duplications within the Epidermal Differentiation Complex (chromosome 1q21) and form a novel S100 subfamily in human. Despite highest homology (>  90 %), psoriasin and koebnerisin are distinct in tissue distribution, regulation… (More)
DOI: 10.1055/s-0031-1299015

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