[Frequency of CYP2A6 gene deletion and its relation to risk of lung cancer].

@article{Gu2005FrequencyOC,
  title={[Frequency of CYP2A6 gene deletion and its relation to risk of lung cancer].},
  author={Yanfei Gu and Shucai Zhang and B. J. P. Lai and Xiuping Zhan and Yi Zhang},
  journal={Zhongguo fei ai za zhi = Chinese journal of lung cancer},
  year={2005},
  volume={8 4},
  pages={297-9}
}
BACKGROUND Cytochrome P450 2A6 (CYP2A6) plays an important role in oxidation of nicotine and in activation of tobacco-related carcinogens. It has been suggested that individuals with defective CYP2A6 allele are at a lower risk of developing lung cancer. This study is to investigate the frequency of CYP2A6 gene deletion and the relationship of CYP2A6 genetic polymorphism with lung cancer risk in Chinese. METHODS A case-control study which detected CYP2A6 genotype of 180 patients with lung… CONTINUE READING