[Flowcharts for the diagnosis and the molecular characterization of hemoglobinopathies].

@article{AguilarMartinez2010FlowchartsFT,
  title={[Flowcharts for the diagnosis and the molecular characterization of hemoglobinopathies].},
  author={Patricia Aguilar-Martinez and C Badens and Nathalie Bonello-Palot and Estelle Cadet and Nathalie Couque and Rolande Ducrocq and Jacques Elion and Alain Francina and Philippe Joly and Serge Pissard and Jacques Rochette},
  journal={Annales de biologie clinique},
  year={2010},
  volume={68 4},
  pages={
          455-64
        }
}
The diagnosis of the main hemoglobinopathies (HbS, HbC, HbE, heterozygous beta-thalassemia) is easy for laboratories using Hb electrophoresis and/or cation-exchange high performance liquid chromatography (CE-HPLC) methods. However, the diagnosis of alpha-thalassemias and of rare Hb variants is much more complex. Six French laboratories, forming together the "Pathologie héréditaire de l'érythrocyte" network, routinely practice the molecular diagnosis of hemoglobinopathies. These laboratories… Expand
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