[First-line treatment of severe myelomas of the young subject by high-dose melphalan].

@article{Harousseau1988FirstlineTO,
  title={[First-line treatment of severe myelomas of the young subject by high-dose melphalan].},
  author={J L Harousseau and N{\"o}el Milpied and François Guilhot and Richard Garand and Jean Henri Bourhis},
  journal={Presse medicale},
  year={1988},
  volume={17 29},
  pages={1471-4}
}
Six patients (aged 39 to 55 years) with stage III myelomas were treated with IV high dose melphalan (HDM) 140 mg/m2. They had previously received only one or two courses of conventional chemotherapy. The extrahematological tolerance of the procedure was good. The duration of neutropenias (less than 500/mm3) was 14 to 24 days. Complete remission (CR) was obtained in 4 cases but one patient died in CR of invasive aspergillosis. In the other 3 cases, bone marrow was cryopreserved without ex vivo… CONTINUE READING