[Failure of rituximab in relapsing neuromyelitis optica: case report with two-year prospective follow-up].

Abstract

Neuromyelitis optica (Devic's disease, NMO) is an inflammatory disease of the central nervous system preferentially involving the spinal cord and optic nerves in either a monophasic or relapsing-remitting course. B-cell induced pathogenesis was recently described for NMO. Rituximab is a chimeric monoclonal antibody directed against the CD20 antigen, which… (More)
DOI: 10.1016/j.neurol.2007.10.009

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