[FGF/FGFR signalling: Implication in oncogenesis and perspectives].

@article{Flippot2015FGFFGFRSI,
  title={[FGF/FGFR signalling: Implication in oncogenesis and perspectives].},
  author={Ronan Flippot and Moumini Kone and Nicolas Magn{\'e} and St{\'e}phane Vignot},
  journal={Bulletin du cancer},
  year={2015},
  volume={102 6},
  pages={516-26}
}
Deregulation of FGF (fibroblast growth factor)/FGFR (fibroblast growth factor receptor) signalling leads to the promotion of several oncogenic mechanisms: proliferation, epithelial-mesenchymal transition, cytoskeleton modifications, migration and angiogenesis. Deregulation of this pathway is reported in various cancers at early stages, and can therefore be responsible for the emergence of the hallmarks of cancer. It is necessary to precise downstream pathways of FGFR signalling to understand… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 55 references

FGFR: proof-of-concept study of AZD4547 in patients with FGFR1 or FGFR2 amplified tumours

  • EC Smyth
  • J Clin Oncol
  • 2013
Highly Influential
10 Excerpts

bFGF as an for human melano 1988;3:177–86

  • R Halaban, BS Kwon, A. Baird
  • JUIN
  • 2015
2 Excerpts

A phase I/IIa study evaluating the safety, efficacy, pharmacokinetics, and pharmacodynamics of lucitanib in advanced solid tumors

  • Soria J-C
  • J Clin Oncol 2014;32:5s
  • 2014
1 Excerpt

A single arm, open-label, phase II study to assess the efficacy of lucitanib in patients with FGFR1-amplified squamous NSCLC (sqNSCLC)

  • DR Spigel
  • J Clin Oncol
  • 2014
1 Excerpt

Exploratory biomarker analysis of a phase I study of AZD4547, an inhibitor of fibroblast growth factor receptor (FGFR), in patients with advanced solid tumors

  • E Kilgour
  • J Clin Oncol 2014;32:5s
  • 2014
1 Excerpt

Similar Papers

Loading similar papers…