[FGF/FGFR signalling: Implication in oncogenesis and perspectives].

  title={[FGF/FGFR signalling: Implication in oncogenesis and perspectives].},
  author={Ronan Flippot and Moumini Kone and Nicolas Magn{\'e} and St{\'e}phane Vignot},
  journal={Bulletin du cancer},
  volume={102 6},
Deregulation of FGF (fibroblast growth factor)/FGFR (fibroblast growth factor receptor) signalling leads to the promotion of several oncogenic mechanisms: proliferation, epithelial-mesenchymal transition, cytoskeleton modifications, migration and angiogenesis. Deregulation of this pathway is reported in various cancers at early stages, and can therefore be responsible for the emergence of the hallmarks of cancer. It is necessary to precise downstream pathways of FGFR signalling to understand… CONTINUE READING


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