• Medicine
  • Published in Nippon Ganka Gakkai zasshi 1994

[Extracellular adenosine-5'-triphosphate increases intracellular calcium concentration of the rabbit eye suprachoroid via activation of the intracellular signal transduction].

@article{Shen1994ExtracellularAI,
  title={[Extracellular adenosine-5'-triphosphate increases intracellular calcium concentration of the rabbit eye suprachoroid via activation of the intracellular signal transduction].},
  author={Yue-liang Shen and K-I. Hirai},
  journal={Nippon Ganka Gakkai zasshi},
  year={1994},
  volume={98 1},
  pages={
          69-74
        }
}
Intracellular calcium concentration ([Ca2+]i) of the rabbit eye suprachoroid was measured with microfluorophotometry using fura-2. Adenosine-5'-triphosphate (ATP) 1-100 microM, added to a perfusing solution, elicited an increase in [Ca2+]i of the suprachoroid. This action of ATP was inhibited when preparations were perfused with a nominally zero Ca2+ Krebs solution or a high magnesium Krebs solution. The [Ca2+]i-increasing action of ATP was attenuated either by lowering temperature or by a… CONTINUE READING