[Extensive cerebral venous thrombosis resistant to heparin: local fibrinolysis with urokinase].

@article{Smadja1997ExtensiveCV,
  title={[Extensive cerebral venous thrombosis resistant to heparin: local fibrinolysis with urokinase].},
  author={Didier Smadja and Myriam Raynaud and Hossein Mehdaoui and Claude Poey and J. N. Drault and Alex Ridarch and François Tixier and Jean Claude Vernant and J-L Mas},
  journal={Revue neurologique},
  year={1997},
  volume={153 4},
  pages={
          271-4
        }
}
A 37 year-old man had headaches for 10 days, then a single tonic-clonic seizure and coma due to an extensive cerebral venous thrombosis. In spite of full-dose heparin treatment for 7 days, the clinical picture worsened along with increasing edema on CT-Scan. Direct thrombolytic treatment was then performed using transvenous catheterization and instillation of Urokinase (2.6 MU over 4 days). A near complete repermeabilization of the sinuses was obtained and the patient improved dramatically in a… CONTINUE READING