[Expression of the partial protein encoded by mutated COL4A5 gene and analysis of the structure by circular dichroism].

Abstract

OBJECTIVE To analyze the protein structure encoded by COL4A5 gene with a missense mutation and to discuss the effect of gene mutation on basic structure and predicted secondary structure of the encoded protein. METHODS A fragment of cDNA with a g.3246G T mutation resulting in p.G1015V from an X-linked Alport patient, and that of corresponding cDNA from a… (More)

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