[Expression and tumoricidal activity of a human-mouse chimeric anti-DR5 antibody through a Furin/2A peptide].

@article{Li2011ExpressionAT,
  title={[Expression and tumoricidal activity of a human-mouse chimeric anti-DR5 antibody through a Furin/2A peptide].},
  author={Meng Li and Fu-jia L{\"u} and Juan Shi and Yan-xin Liu and De-xian Zheng},
  journal={Zhonghua yi xue za zhi},
  year={2011},
  volume={91 10},
  pages={707-10}
}
OBJECTIVE To express a full-length human-mouse chimeric anti-DR5 antibody from a single open reading frame with tumoricidal activity to various cancer cells. METHODS The heavy and light chains of chimeric antibody were joined by the Furin and 2A (F/2A) self-cleavage peptide and cloned into a lentiviral vector of pWPXL. Then the HEK293 cells were infected… CONTINUE READING