[Expression and antagonist role of endothelin and nitric oxide synthase in atherosclerotic plaque].

@article{Song1997ExpressionAA,
  title={[Expression and antagonist role of endothelin and nitric oxide synthase in atherosclerotic plaque].},
  author={Lun Song and Dong Wang and Tingting Wang},
  journal={Zhonghua bing li xue za zhi = Chinese journal of pathology},
  year={1997},
  volume={26 1},
  pages={12-5}
}
OBJECTIVE To study the pathogenetic mechanism of atherosclerotic plaque, the action of mediation and antagonism of endothelin (ET) and nitric oxide synthase (NOS) was investigated. METHODS In situ hybridization, RT-PCR on endothelin and NOS, cytochemistry on NOS were measured using the rabbit atherosclerosis model and cultured vascular smooth muscle cells (VSMC) from normal rabbit. RESULTS Transcription of endothelin mRNA increased and transcription of NOS mRNA decreased in astherosclerotic… CONTINUE READING