Corpus ID: 42087836

[Experiments on the mechanism of action of vascular spasmolytics. 4. Effect of nitroprusside sodium, nitroglycerin, prenylamine and verapamil on the calcium uptake of microsomes of the smooth bascular muscles].

@article{Klinner1977ExperimentsOT,
  title={[Experiments on the mechanism of action of vascular spasmolytics. 4. Effect of nitroprusside sodium, nitroglycerin, prenylamine and verapamil on the calcium uptake of microsomes of the smooth bascular muscles].},
  author={U. Klinner and D. Ehlers and R. Fermum and P. Meisel},
  journal={Acta biologica et medica Germanica},
  year={1977},
  volume={36 7-8},
  pages={
          1143-8
        }
}
Nitroprusside-sodium, nitroglycerol, and verapamil had no effect on the calcium uptake by microsomes from the carotid artery of cattle. Prenylamine reduced the passive binding and the active uptake and released already bound calcium. The basal Mg-dependendent ATPase and Ca-stimulatable Mg-ATPase were inhibited by prenylamine. 
1 Citations
The isolation and characterization of Ca++-accumulating subcellular membrane fractions from cerebral arteries.
TLDR
A study was undertaken using differential centrifugation methods to isolate from rabbit cerebral arteries the subcellular microsomal protein fractions capable of actively sequestering Ca++, and it was concluded that thismicrosomal fraction consisted primarily of sarcoplasmic reticulum. Expand