[Experimental techniques for developing new drugs acting on dementia (10)--Alzheimer's disease animal model induced by beta-amyloid protein].

@article{Nitta1996ExperimentalTF,
  title={[Experimental techniques for developing new drugs acting on dementia (10)--Alzheimer's disease animal model induced by beta-amyloid protein].},
  author={Atsumi Nitta and Toshitama Nabeshima},
  journal={Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology},
  year={1996},
  volume={16 3},
  pages={85-90}
}
To develop an animal model of Alzheimer's disease, beta-amyloid protein was infused into the rat cerebral ventricle for 14 days using a mini-osmotic pump. The performance of some memory tasks in the beta-amyloid protein-treated rats was impaired. Long-term potentiation in the hippocampus was impaired in beta-amyloid-infused rats. The impairment of memory under the infusion could be recovered by two cognitive enhancer drugs. Choline acetyltransferase activity significantly decreased in the… CONTINUE READING