[Experimental study on effect of anhydroicaritin phytosomes in preventing and treating bone loss and enhancing bone quality in ovariectomized osteoporosis rats].

@article{Wu2013ExperimentalSO,
  title={[Experimental study on effect of anhydroicaritin phytosomes in preventing and treating bone loss and enhancing bone quality in ovariectomized osteoporosis rats].},
  author={Mi-Shan Wu and Suzhi Zhao and Lizhong Ren and Ru Wang and Xia Bai and Hongwei Han and Bin Li},
  journal={Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica},
  year={2013},
  volume={38 13},
  pages={
          2163-8
        }
}
  • Mi-Shan Wu, Suzhi Zhao, +4 authors B. Li
  • Published 1 July 2013
  • Medicine
  • Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
OBJECTIVE To explore the effect of anhydroicaritin phytosomes (AIP) in preventing and treating bone loss and enhancing bone quality in ovariectomized osteoporosis rats. METHOD Seventy-two SD female rats were randomly divided into 6 groups: the sham group, the model group, the estrogen group and AIP groups (low, middle, high). The sham group was only sham operated, and the remaining five groups were ovariectomized. One week after the ovariectomy, the rats were given 17 beta-estrogen and AIP… 
Pycnogenol(®) treatment inhibits bone mineral density loss and trabecular deterioration in ovariectomized rats.
TLDR
Pycnogenol(®) (40 mg/kg) can inhibit aggravated bone resorption, prevent BMD loss, and restore the impaired trabecular microarchitecture in OVX rats after 9-week-intervention.
Chinese single herbs and active ingredients for postmenopausal osteoporosis: From preclinical evidence to action mechanism.
TLDR
This article reviews the experimental evidence of both in vitro and in vivo preclinical studies of the application of Chinese single herbs and active ingredients in postmenopausal osteoporosis and investigates the underlying mechanisms including osteoprotegerin/receptor activator of nuclear factor κB ligand (OPG/RANKL).