[Experimental study on concentrations and pharmacokinetics of antibiotics in bile and evaluation of their microbicidal potential].

@article{Zheng2014ExperimentalSO,
  title={[Experimental study on concentrations and pharmacokinetics of antibiotics in bile and evaluation of their microbicidal potential].},
  author={Jinglei Zheng and Lijian Liang and Zaiguo Wang and Bao-Gang Peng and Shaoqiang Li and Jiaming Lai},
  journal={Zhonghua wai ke za zhi [Chinese journal of surgery]},
  year={2014},
  volume={52 10},
  pages={
          775-80
        }
}
OBJECTIVE To study the concentrations and pharmacokinetics of 6 different kinds of antibiotics in rabbit bile, and evaluate their microbicidal potential. METHODS Thirty-six health rabbits were randomly divided into 6 groups, and each group was 6 rabbits. After anaesthesia, the common bile duct of rabbit was isolated and cumulated with a silicone tube. The rabbits were administered intravenously with the equal-effect dose of antibiotics. Bile (1.5 ml) was collected at different time points… CONTINUE READING