Corpus ID: 7452778

[Experimental study of NK4 gene targeted therapy mediated by human telomerase reverse transcriptase promoter for colon cancer].

@article{Xu2010ExperimentalSO,
  title={[Experimental study of NK4 gene targeted therapy mediated by human telomerase reverse transcriptase promoter for colon cancer].},
  author={Bo Xu and Hu Xiao and S. Zeng and Guidong Huang and Zhen-bang Liu and Yue-jun Qian and Shu-hua Li},
  journal={Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery},
  year={2010},
  volume={13 11},
  pages={
          851-4
        }
}
  • Bo Xu, Hu Xiao, +4 authors Shu-hua Li
  • Published 2010
  • Medicine
  • Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
OBJECTIVE To investigate anti-tumor effect of the recombined adenovirus encoding NK4 gene regulated by human telomerase reverse transcriptase (HTERT) promoter (Ad HTERTp-NK4) on human colon cancer. METHODS Colon cell line HCT116 was infected with Ad HTERTp-NK4. NK4 expression was determined by RT-PCR and Western blot. The cell-growth inhibition rate and the invasive capacity of cells were evaluated by MTT method and reconstituted basement membrane invasion assay. The model of subcutaneous… Expand