• Corpus ID: 37943790

[Experimental epidural and conduction anesthesia with azacaine].

  title={[Experimental epidural and conduction anesthesia with azacaine].},
  author={Iryna Cherniakova and Viktor Nikolaevich Zhukov and S A Osipov and A Sh Shadiev and T V Skovpen'},
  journal={Eksperimental'naia i klinicheskaia farmakologiia},
  volume={57 1},
Experimental studies were undertaken to examine azacaine used in mice during conduction anesthesia and in rabbits during epidural anesthesia in 0.75, 2 and 0.75, 1% solutions, respectively. It was found that azacaine in the above doses is 1.5-3.5-fold superior to 2% solutions of lidocaine (xycaine) and trimecaine (mesocaine) in their effect duration. Histological studies of the rabbit spinal cord after epidural azacaine administration revealed no significant changes in brain tissues. 
2 Citations

Local Anesthetic Activity

The mode of action of local anesthetics has been reviewed by Ritchie and Greengard (1966), Ritchie (1971), Borchard (1977), Steiner (1978), and Butterworth and Strichartz (1990).