[Experimental chronic paraquat poisoning. Functional and histopathological pulmonary changes].

@article{Saunier1982ExperimentalCP,
  title={[Experimental chronic paraquat poisoning. Functional and histopathological pulmonary changes].},
  author={C G Saunier and Francine Schrijen and J. P. Gille and Prof Dan Horsky and Ren{\'e} Peslin and D. Hartemann and Bernard Foliguet and H{\'e}l{\`e}ne Lambert},
  journal={Bulletin europeen de physiopathologie respiratoire},
  year={1982},
  volume={18 6},
  pages={863-76}
}
An experimental model of pulmonary interstitial fibrosis was attempted in beagle dogs by intravenous administration of weak doses of paraquat. After various trials, the final protocol involved the intravenous injection of 2 mg/kg repeated every eight days for three weeks, and then every 15 days. On the 70th day, areas of localized interstitial fibrosis were observed (less than 10% of the surface of the tissue sections) in an otherwise healthy parenchyma. There was no marked hepatic or renal… CONTINUE READING

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