[Evaluation of theophylline population pharmacokinetics in adult hospitalized patients using NONMEM analysis].

  • Z. Li, G. Chen
  • Published 1994 in
    Zhongguo yao li xue bao = Acta pharmacologica…


The population pharmacokinetics of theophylline was evaluated using 374 theophylline serum concentration measurements from 72 hospitalized patients through NONMEM analysis. An one-compartment open pharmacokinetic model with first-order absorption and first-order elimination was used. The effects of a variety of factors on Cl and Vd were investigated… (More)


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