Corpus ID: 21383195

[Evaluation of the toxicity of indorenate on reproduction].

  title={[Evaluation of the toxicity of indorenate on reproduction].},
  author={G. Chamorro and M. Mart{\'i}nez and M. Salazar and S. Salazar and E. Hong},
  journal={Archivos del Instituto de Cardiologia de Mexico},
  volume={65 4},
Indorenate (TR3369) a new antihypertensive drug, was examined for effects upon general reproductive performance, for peri-postnatal and embryofetal toxicity in the rat at doses of 0, 10, 20, 40 and 60 mg/kg/day by oral administration. Excluding the 60 mg/kg dose, in the fertility study, any dose produced neither decrement of body weight gain of progenitors, fertility, fetal weight nor survival rate. Retardation of the surface righting, pinnal unfolding or startle response were not observed. On… Expand