[Erythrophagocytosis and recycling of heme iron in normal and pathological conditions; regulation by hepcidin].

@article{Beaumont2005ErythrophagocytosisAR,
  title={[Erythrophagocytosis and recycling of heme iron in normal and pathological conditions; regulation by hepcidin].},
  author={Carole Beaumont and François Canonne-Hergaux},
  journal={Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine},
  year={2005},
  volume={12 2},
  pages={123-30}
}
Most of the iron required for erythropoiesis is provided by heme iron recycling following degradation of senescent erythrocytes by tissue macrophages. Accumulation of biochemical modifications at the red blood cell membrane during ageing (externalisation of phosphatidyl-serine, peroxydation of membrane-bound lipoproteins, loss of sialic acid residues and formation of senescence neoantigens) constitute a series of signals that will allow the macrophage to identify the red blood cells to be… CONTINUE READING