• Corpus ID: 39027003

[Eremomycin in the treatment of antibiotic-associated colitis in golden hamsters].

@article{Rukhlina1992EremomycinIT,
  title={[Eremomycin in the treatment of antibiotic-associated colitis in golden hamsters].},
  author={A A Rukhlina and L. A. Malkova and L A Shevniuk and T. V. Fomina and V. M. Bukhman and V M Koroleva and IS Bakulin and T. I. Sergeeva},
  journal={Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]},
  year={1992},
  volume={37 3},
  pages={
          20-2
        }
}
The efficacy of eremomycin, a new glycopeptide antibiotic, was studied on a model of antibiotic-associated colitis in golden hamsters. The colitis was induced by intraperitoneal or intragastric administration of lincomycin. In a dose of 100 mg/kg administered orally once a day for 5 days eremomycin protected the animals from the lincomycin-induced colitis: some animals survived, the others died in later periods. When the animals were infected with a pathogenetic strain of Clostridium difficile… 
1 Citations
Models for the study of Clostridium difficile infection
TLDR
Experiments using models have major advantages over clinical studies and have been indispensible in furthering C. difficile research, so it is important for future study programs to carefully consider the approach to use to inform the design and interpretation of clinical studies.