[Enterovirus 71 induces apoptosis in a Bax dependent manner].

  title={[Enterovirus 71 induces apoptosis in a Bax dependent manner].},
  author={Zhen-min Sun and Yan Xiao and Li-li Ren and Xiao-bo Lei and Jianwei Wang},
  journal={Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology},
  volume={25 1},
OBJECTIVE To explore the molecular mechanism of apoptosis induced by enterovirus 71 (EV71) infection. METHODS The effects of EV71 on Rhabdomyosarcoma (RD) cell viability were detected by CCK8 assay. EV71-induced apoptosis on RD cells were detected by Hoechst 33342 staining and Western blot targeting Caspase 3, 8 and PARP. Bax conformational change was detected by immunoprecipitation with Bax 6A7 antibody. RESULTS EV71 decreased the viability of RD cells and induces the activation of Caspase… CONTINUE READING

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