[Enhanced cytotoxicity of VM-26 in human malignant glioma cells by calcium channel blocker nicardipine in vitro].

@article{Hu1999EnhancedCO,
  title={[Enhanced cytotoxicity of VM-26 in human malignant glioma cells by calcium channel blocker nicardipine in vitro].},
  author={S Hu and Changzheng Huang and Brenden Yi-kuang Chen},
  journal={Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University},
  year={1999},
  volume={24 2},
  pages={143-6}
}
Using the monolay tumor cell culture system and the method or MTT colorimetric analysis, the cytotoxicity of the anticancer drug VM-26 and Nicardipine(NCDP) in human malignant glioma cell line U251 was studied. The results showed that the cytotoxicity of VM-26 in U251 was enhanced by NCDP at a low dose which did not show direct cytotoxicity. The authors considered that VM-26 combined with NCDP can heighten the intracellular anticancer drug concentration, reverse the drug resistance and… CONTINUE READING