[Endothelium-derived hyperpolarizing factor and vasodilatation].

  title={[Endothelium-derived hyperpolarizing factor and vasodilatation].},
  author={Hiroaki Suzuki and Yoshimichi Yamamoto and Hiroyasu Fukuta},
  journal={Nihon yakurigaku zasshi. Folia pharmacologica Japonica},
  volume={112 3},
Properties of endothelium-derived hyperpolarizing factor (EDHF) have been reviewed briefly. The production of EDHF requires an increase in endothelial [Ca2+]i, the properties being similar to those of nitric oxide (NO). EDHF activates K(+)-channels and hyperpolarizes vascular smooth muscle. The EDHF-induced hyperpolarization is greatly inhibited by charybdotoxin (ChTX) and partially inhibited by apamin, but not by K(+)-channel inhibitors such as Ba2+, glibenclamide, 4-aminopyridine, suggesting… CONTINUE READING