[Endothelial dysfunction and atherosclerosis].

  title={[Endothelial dysfunction and atherosclerosis].},
  author={Paul Michel Vanhoutte},
  journal={Archives des maladies du coeur et des vaisseaux},
  volume={90 Spec No 6},
Mammalian endothelium acts as a mediator in arterial and venous relaxation and contraction. Endothelium-dependent relaxation is due to endothelial release of powerful, non-prostanoid vasodilatory substances. The best known of these is the endothelial factor EDRF identified as nitrous oxide (NO). It is the end result of the metabolism of L-arginine by the NO synthetase of endothelial cells. In arterial smooth muscle, the relaxation induced by EDRF is explained by NO stimulation of soluble… CONTINUE READING


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